The 2025 ICD-10-CM Professional for Physicians with Guidelines, with its hallmark features and format, makes the challenge of accurate diagnosis coding easier. Developed specifically to meet the needs of physicians, the Optum360 codebook contains the complete ICD-10-CM code set, which is the cornerstone for establishing medical necessity, determining coverage, and ensuring appropriate reimbursement. Symbols in the tabular section identify codes associated with CMS quality payment program (QPP) measures and CMS hierarchical condition categories (HCC) used in risk adjustment (RA) coding.